Senior Research Scientist – Biochemical & Cellular Assays

Job type: Full-Time
Accepting BioReady™: Yes
Category: Clinical Research
Employer: Repare Therapeutics Inc.
Salary:
Location: Montreal, QC
Posted: January 15, 2020
Closes: February 14, 2020

Repare Therapeutics develops novel, precision oncology drugs that target specific vulnerabilities of tumor cells. Repare integrates insights from several fields of cell biology including DNA repair and synthetic lethality, combining a proprietary, high throughput, CRISPR‐enabled gene editing target discovery method with high‐resolution protein crystallography, computational biology, drug discovery and clinical informatics.  Repare was founded by leading experts at the forefront of DNA damage and repair cancer biology and genome-scale synthetic lethal screening technologies.  The company has assembled a seasoned team of industry veterans and a world-class Advisory Board to support the development of next generation precision oncology, small-molecule therapeutics.  Repare Therapeutics is a 2017 “Fierce 15” start-up backed by tier-one strategic and institutional biotechnology investors (http://www.reparerx.com).

Repare Therapeutics is seeking a highly motivated and team-oriented research scientist to join our biology department and help advance our portfolio of synthetic lethal cancer therapies. The individual should have extensive knowledge in developing and running biochemical &/or cell-based assays to support lead identification and lead optimization activities. A good understanding of assay miniaturization and automation is needed. Candidates must have the ability to communicate clearly, collaborate and enjoy a fast-paced and hands-on research environment.

RESPONSIBILITIES 

  • Independently develop complex target-based assays in both biochemical and/or cell-based systems to support structure-activity relationship (SAR) studies on various target screens
  • Program and use specialized equipment (ie. plate readers, robotic reagent dispensing) for assay miniaturization needs
  • Knowledge of enzymology and protein-protein interaction is an asset
  • Establish procedures for new assays and be responsible for calculating and reporting data and procedures in an electronic lab book
  • Critically analyze and interpret data using various software, and effectively document and communicate results to a variety of audiences
  • Execute a wide array of technical methods including molecular biology (cloning, PCR, QPCR, western blot) and/or cell culture 
  • Good organizational and time-management skills including the ability to manage several projects simultaneously
  • Ability to work as a team member in a dynamic, fast-paced biotech environment where you can make a clear impact

QUALIFICATIONS

  • MSc or PhD Degree in cell biology, molecular biology, biotechnology or biochemistry; 
  • At least 5 years of experience in drug discovery in a pharmaceutical/ biotechnology/contract research organization setting (CRO)/ academic platform
  • Strong knowledge and experience in data analysis and reporting is required
  • Hands-on experience with miniaturization and automation is a must
  • Strong analytical capabilities with understanding of early drug discovery is essential
  • Excellent communication skills. Ability to communicate in an open, clear, timely and consistent manner
  • Outstanding organizational skills (lab book, experimental design, reagent cataloging, etc.)
  • Excellent teamwork approach – work as part a cross-functional team including biologists, medicinal chemists and structural biologists
Apply Now