Scientist, Analytics

Type d’emploi: Temps plein
Candidats BioFin prêtsᴹᶜ acceptés : Oui
Catégorie: Recherche clinique
Éducation Doctorat
Expérience: 0-3 Years
Employeur : Zymeworks Inc.
Lieu : Vancouver, BC
Date de publication : 21 juin 2024
Closes: 21 juillet 2024

Department:  Analytics

Workplace Type: On-Site

Zymeworks is a publicly listed (NASDAQ:ZYME) clinical-stage biopharmaceutical company dedicated to the discovery, development and commercialization of next-generation, bispecific and multifunctional biotherapeutics, initially focused on the treatment of cancer.   Zymeworks’ suite of complementary therapeutic platforms and its fully-integrated drug development engine provide the flexibility and compatibility to precisely engineer and develop highly-differentiated product candidates.

Why Work With Us

Nothing is more critical to our success than the quality of our team.   The work we do is meaningful and impactful – we care about each other as well as the patients we serve.  We offer challenging career opportunities, competitive benefits and an environment that recognizes and rewards performance.

Zymeworks is proudly headquartered in our brand new, net-zero facility located in the vibrant Main St biotech hub of Vancouver, BC, with operations in Bellevue, WA, Dublin, Ireland, Singapore and the Bay Area.

Work Requirement

This position will report to the Senior Scientist & Group Lead, Analytics, ADC Therapeutic Development, and will be based full time onsite in our Vancouver, BC office.

Key Responsibilities

  • Design, implement, evaluate and optimize LC-MS (Q-TOF, Orbitrap and QQQ) based analytical methods for the qualitative and quantitative characterization of antibodies and ADCs.
  • In-depth knowledge and execution of protein characterization including amino acid sequence confirmation, identification and quantitation of post-translational modifications, integrity analysis, sequence variant analysis, intact/reduced mass analysis.
  • Lead and supervise analytical method transfer, validation, and sample analysis to support non-GLP and GLP stage animal studies; understand the project progress and timeline and complete the transfer and validation of analytical methods according to the project requirements.
  • Utilize methods including chromatography, CE-SDS, ciEF, DSF, BLI, SPR and KinExA for the biophysical characterization of proteins and antibody-antigen interactions
  • Assess critical attributes of ADC candidates including by quantifying free payload, antibody-conjugated payload level, drug-to-antibody ratio, total antibody, and other key parameters.
  • Explore and evaluate emerging technologies in the field of ADC therapeutic discovery to improve throughput, precision, accuracy, capabilities, and overall quality of methods employed.
  • Actively engage with scientific literature, industry publications and internally generated data to enhance project understanding.
  • Communicate within and across organizations to align methodology and share analytical findings.
  • Assist in preparation and co-authoring of patent applications, research reports and/or scientific publications.
  • Provide leadership, mentorship, and scientific/technical guidance to junior staff.
  • May present at relevant scientific conferences on behalf of Zymeworks.
  • Adhere to Zymeworks’ standard procedures for generating, documenting, and archiving data, maintaining an accurate, up-to-date electronic laboratory notebook.
  • Conduct all activities in accordance with scientific standards, OS&H regulations and established Zymeworks’ policies and practices. Contributes to a safe and highly efficient laboratory environment.
  • Actively works to foster an environment of effective and collaborative working relationships amongst employees, management, and external partners.

Education and Experience

  • Requires a PhD in biochemistry, analytical chemistry, or related fields with 2 or more years of relevant work experience, or an equivalent combination of education and work experience.
  • In-depth knowledge and hands on experience with different mass spectrometry instruments like Q-TOF, QQQ and Orbitrap.
  • Experience with managing CRO analytical method development and validation is an asset.
  • Knowledge of regulatory processes is an asset.
  • Ability to manage multiple projects, prioritize work, allocate resources, and deliver on deadlines.
  • Excellent analytical and problem-solving capabilities, as well as excellent verbal and written communication skills including presentation of complex data.
  • Adhere to the highest degree of professional standards and strict confidentiality on matters that require discretion.

Skills and Abilities

  • Strong organizational and time management skills, work effectively in a fast paced, fast changing environment.
  • Excellent interpersonal skills with the ability to work collaboratively as a member of a cross-functional team; ability to establish and maintain effective working relationships.
  • Excellent communication skills, including scientific/technical writing and oral skills. Ability to present data effectively at large team meetings or interdepartmental meetings.
  • Demonstrated leadership and mentorship skills.
  • Results oriented.
  • In depth knowledge of antibody or antibody drug conjugate structure/function.
  • Advanced knowledge in icIEF, CE-SDS, SPR, BLI and HPLC based chromatography (SEC, HIC, RP).
  • Experience with Agilent Q-TOF, QQQ, Thermo Fisher Orbitrap Mass Spectrometry instruments and related data analysis software is a bonus.

Total Rewards

We offer a comprehensive total rewards package, which includes competitive salaries, generous benefits, an outstanding work environment, and excellent opportunities for professional growth.  We regularly benchmark our compensation against leading biotechnology companies in our geographies.

The Canadian base salary range for this full time position is $94,000 – $144,000 + bonus + equity + benefits. Our salary ranges are determined by role, level, and location.

The range displayed on each job posting reflects the minimum and maximum target for new hire salaries for the position across all Canadian locations. Within the range, individual pay is determined by a variety of factors and the salary offered may vary depending on the successful candidate’s location and qualifications (including, but not limited to, job-related knowledge, education, training, skills, and experience).

Please note that the compensation details listed in role postings reflect the base salary only, and do not include bonus, equity, or benefits.

Our team enjoys: 

  • Industry leading vacation and paid time off
  • Excellent health and wellness benefits
  • Zymelife health and wellness benefits
  • Paid time off to volunteer in your community
  • Matching country specific pension savings program
  • Employee Share Purchase Program
  • Employee Equity Program

All qualified applicants will receive consideration for employment without regard to race, colour, religion, sex, sexual orientation, gender identity, national origin or disability.

 

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