Associate Scientist, In Vitro Biology

Type d’emploi: Temps plein
Candidats BioFin prêtsᴹᶜ acceptés : Oui
Catégorie: Recherche clinique
Éducation Doctorat
Expérience: 0-3 Years
Employeur : Zymeworks Inc.
Salaire : $86,000 - $132,000
Lieu : Vancouver, BC
Date de publication : 21 juin 2024
Closes: 21 juillet 2024

Department: In Vitro Biology

Workplace Type: On-Site

Company Description

Zymeworks is a publicly listed (NASDAQ:ZYME) clinical-stage biopharmaceutical company dedicated to the discovery, development and commercialization of next-generation, bispecific and multifunctional biotherapeutics, initially focused on the treatment of cancer.   Zymeworks’ suite of complementary therapeutic platforms and its fully-integrated drug development engine provide the flexibility and compatibility to precisely engineer and develop highly-differentiated product candidates.

Why Work With Us

Nothing is more critical to our success than the quality of our team.   The work we do is meaningful and impactful – we care about each other as well as the patients we serve.  We offer challenging career opportunities, competitive benefits and an environment that recognizes and rewards performance.

Zymeworks is proudly headquartered in our brand new, net-zero facility located in the vibrant Main St biotech hub of Vancouver, BC, with operations in Bellevue, WA, Dublin, Ireland, Singapore and the Bay Area.

Zymeworks is seeking an Associate Scientist to join the In Vitro Biology group within the ADC Therapeutic Development department. The In Vitro Biology group is responsible for the in vitro functional characterization and advancement of Antibody Drug Conjugate (ADC) therapeutic candidates and platform technologies. The successful candidate will be part of a dynamic and motivated team supporting the advancement of novel platform technologies within our ADC therapeutic pipeline. Demonstrates enthusiasm for ongoing learning, actively seeking to enhance expertise in emerging concepts and innovative biology. The candidate will be challenged to critically analyze results and contribute to the Zymeworks team effort to create clinically and commercially relevant therapeutics.

Work Requirement

This position will report to the Scientist & Group Lead, In Vitro Biology, ADC Therapeutic Development and will be based full time onsite in Vancouver, BC office.

Key Responsibilities

  • Oversees the design, coordination, execution, and analysis of in vitro pharmacology experiments for the screening and progression of novel technologies for ADCs.
  • Functionally characterizes small molecules, antibodies, bioconjugates, or ADCs using various cell-based assays and techniques including flow cytometry, high throughput screening, live cell imaging, 3D tissue culture, and other methods as required to support pipeline project advancement.
  • Leads and executes novel assay development initiatives. Designs and troubleshoots novel methods to profile the mechanism of action of ADCs across multiple payload classes.
  • Applies knowledge of cancer biology, medicinal chemistry, and other scientific methodologies in conducting technically advanced analyses and data interpretations.
  • Effectively collaborates with members outside of their immediate team to coordinate execution of decision-making experiments for different projects and routinely shares progress updates with the team.
  • Prepares and disseminates data presentations for group meetings, summarizing results and next steps. Acts as area representative in specific projects.
  • Provides leadership, mentorship, and scientific/technical guidance to junior staff.
  • Supports mammalian tissue culture activities within the group. Works with team to ensure cell lines are properly expanded, cryopreserved and databases updated as required.
  • May co-author or author scientific papers, conference disclosures, patents, and/or regulatory documents.
  • May present at relevant scientific conferences on behalf of Zymeworks
  • Adheres to Zymeworks standard procedures for generating, documenting, and archiving data, maintaining an accurate, up-to-date electronic laboratory notebook.
  • Conducts all activities in accordance with scientific standards, OS&H regulations and established Zymeworks’ policies and practices. Contributes to a safe and highly efficient laboratory environment.
  • Actively works to foster an environment of effective and collaborative working relationships amongst employees, management, and external partners.
  • Education and Experience
  • Associate Scientist: Requires a PhD in Molecular Biology, Immunology, Biochemistry with a minimum 1-2 years’ relevant work experience, or equivalent combination of education and work experience.
  • Demonstrated experience with cell-based or biochemical assay development.
  • Demonstrated understanding of in vitro cancer models and therapeutic mechanisms of actions.
  • Experience with characterization and analysis of biotherapeutics (small molecules, antibodies, Fc-fusion proteins, ADCs or other immunoconjugates) is an asset.
  • Experience with high-throughput screening assays and workflows is an asset.

Skills and Abilities

  • Ability to manage multiple projects, prioritize work, allocate resources, and deliver on deadlines.
  • Excellent analytical and problem-solving capabilities.
  • Adhere to the highest degree of professional standards and strict confidentiality on matters that require discretion.
  • Strong organizational and time management skills, work effectively in a fast paced, fast changing environment.
  • Excellent interpersonal skills with the ability to work collaboratively as a member of a cross-functional team; ability to establish and maintain effective working relationships.
  • Excellent communication skills, including scientific/technical writing and oral skills. Ability to present data effectively at large team meetings or interdepartmental meetings.
  • Demonstrated leadership and mentorship skills.
  • Results oriented.
  • In depth knowledge of antibody or antibody drug conjugate structure/function.
  • Knowledge of GraphPad and FlowJo softwares, or similar software, considered an asset.
  • Advanced knowledge and proficiency in the following techniques:
  • Flow cytometry
  • High-content analysis or fluorescence imaging
  • Mammalian tissue culture
  • Immunological/co-culture assays considered an asset

Total Rewards

We offer a comprehensive total rewards package, which includes competitive salaries, generous benefits, an outstanding work environment, and excellent opportunities for professional growth.  We regularly benchmark our compensation against leading biotechnology companies in our geographies.

The Canadian base salary range for this full time position is $86,000 – $132,000 + bonus + equity + benefits. Our salary ranges are determined by role, level, and location.

The range displayed on each job posting reflects the minimum and maximum target for new hire salaries for the position across all Canadian locations. Within the range, individual pay is determined by a variety of factors and the salary offered may vary depending on the successful candidate’s location and qualifications (including, but not limited to, job-related knowledge, education, training, skills, and experience).

Please note that the compensation details listed in role postings reflect the base salary only, and do not include bonus, equity, or benefits.

Our team enjoys: 

  • Industry leading vacation and paid time off
  • Excellent health and wellness benefits
  • Zymelife health and wellness benefits
  • Paid time off to volunteer in your community
  • Matching RRSP / 401K program
  • Employee Share Purchase Program
  • Employee Equity Program

All qualified applicants will receive consideration for employment without regard to race, colour, religion, sex, sexual orientation, gender identity, national origin or disability.

NOTE TO AGENCIES:  Zymeworks values our relationships with our recruiting partners.  We only accept resumes from those partners who have been contracted with us.  Zymeworks is not responsible for any fees related to resumes that are unsolicited or are received without contract.

 

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