Job Details

Scientific Associate

Scientific Associate
Accepting BioReady
Full Time

Lunenfeld-Tanenbaum Research Institute

$75, 000 – $85, 000
Date Posted
03/05/2018 - 16:00
Closing Date
03/06/2018 - 16:00
Job Description


POSITION TITLE: Scientific Associate

DEPARTMENT/ UNIT: Lunenfeld-Tanenbaum Research Institute

EMPLOYMENT TYPE: Temporary full-time 2 year contract

HOURS OF WORK: 37.5 hours per week

SALARY RANGE: $75, 000 – $85, 000

WORK ADDRESS: Lunenfeld Tanenbaum Research Institute 600 University Avenue, Toronto Ontario  M5G 1X5




Scientific Associate Position

We are seeking a highly motivated Scientific Associate with a life sciences Ph.D. degree (in neuroscience) and substantial, proven post-doctoral research experience  (minimal 6 years) in live cell electrophysiology and multiphoton imaging.  The candidate must be skilled in whole-cell patch-clamp recording and multiphoton imaging of acutely prepared rodent brain slices, dissociated primary cultured neurons and organotypic cultured slices.  The successful candidate will have demonstrated, experienced at successfully supervising and mentoring trainees, willing to develop new in vitro and in vivo multiphoton and super-resolution microscopy imaging assays.


Education & Qualifications: 

Position Requirements:

  •  Ph.D. degree in neuroscience or a related discipline. 
  • Minimum of 6 years of post-doctoral neuroscience experience at leading institutions
  • Demonstrated knowledge of synaptic plasticity
  • Minimum of 5 peer-reviewed synaptic neuroscience original articles published in leading journals, with at least 2 of them consisting of first-author publications
  • Proven proficiency in the techniques of hippocampal whole-cell patch clamp electrophysiology of neurons (acute slices, organotypic slices, and cultured neurons)
  • Proven expertise in measurement of synaptic responses and synaptic plasticity
  • Proven proficiency in multiphoton microscopy including live cell imaging
  • Proven expertise in the development and use of rodent models of neurodevelopmental disorders
  • Proficiency in transduction of neuronal cells.
  • Proven expertise in optogenetics (reporters and/or actuators).
  • Experience in biochemical techniques
  • Record of effective supervision and mentoring of trainees
  • Proven record of successful communication and collaboration

The Scientific Associate will be responsible for managing and helping direct a new Centre for Optophysiology (CfO) based out of the University of Toronto, Department of Physiology, in partnership with SickKids Hospital and Mt. Sinai Hospital.  In consultation with the CfO Executive (Dr. Graham Collingridge, Scientific Director), the candidate will oversee the strategic direction of projects and accrual of scientific milestones. The scientist will develop specifications for equipment purchase in consultation with the Executive and users. Additional duties include implementation of infrastructure, overseeing operations, up keep of the systems, monitoring and approval of facility expenses, staffing and training of the facility staff. The candidate will plan for project sustainability including sourcing funds for ongoing operations and upgrades. They will coordinate reporting to funders and stakeholders of project outputs and outcomes including those relating to recruitment and training of Highly Qualified Personnel (HQP), impact of scientific outcomes, knowledge transfer and commercialization.  The successful candidate will maintain the optophysiology systems and be available to ensure seamless operation on a day-to-day basis. They will formulate training plans, booking calendars, and oversee maintenance and repairs of the instruments, sourcing and procuring specialized supplies and maintaining records of usage. They will serve as a knowledge base for technical aspects of facility operations and keep current knowledge of the field and instruments. The candidate will ensure that the infrastructure operates at maximum capacity and optimised to support as many projects as practically possible.

Duties & Responsibilities: 

The successful applicant will assist researchers with their optophysiological experiments, offering support in neuronal culturing, acute slice preparation, cellular electrophysiology, optogenetics, multiphoton imaging and other techniques employed by the Centre for Optophysiology.

The candidate will also interact directly with the Director’s research laboratory, located at the Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital (affiliated with University of Toronto). The lab is studying synaptic plasticity mechanisms, with a focus on the role of glutamate receptors and the hippocampus in health and disease models.  The successful applicant is expected to run at least one major project within the field of interest of the Director.

Other Information: 

We are located in the Toronto Discovery District which represents one of the largest neuroscience communities in North America.  The lab, facilities and Institutes are very well equipped and have a variety of tools and techniques including mouse models, neurobehavioural testing, in vitro and vivo optical and electrical recordings, multiphoton and fluorescence imaging, genetics, proteomics and biochemistry. The candidate will need to have experience with these techniques.  The successful candidate will interact with scientists at several locations and thus the position requires expertise in communication and collaboration that needs to be substantiated.