Job Details

Research Associate- Formulation

Title
Research Associate- Formulation
Length
Full Time
Employer

Immunovaccine Inc.

Salary
not disclosed
Location
Halifax
Nova Scotia
Date Posted
10/01/2018 - 15:45
Closing Date
10/02/2018 - 15:45
Job Description
Summary: 

Immunovaccine is seeking a highly motivated and scientifically talented person to join our team as a Research Associate. This position is part of manufacturing and provides a great opportunity to formulate and characterize protein/peptides/nucleic acids in lipid based nanoparticles DepoVaxTM platform for the treatment of cancer and wide range of infectious diseases. The major responsibilities include but not limited to liposomes/nanoparticles based vaccine preparation and characterization, support sterile filter validation studies and release of final product. Act as a team player to support pre-clinical, toxicology and stability testing research work by providing the necessary formulations. Manage manufacturing supplies procurement which includes clinical kit components and shipping of DepoVaxTM vaccine formulations to external collaborators and clinical sites.

    Education & Qualifications: 

    Minimum requirements:

    • Post secondary education in Chemistry/Analytical Chemistry/Biochemistry/Pharmacy or with pharmaceutical sciences background.
    • A B.Sc. with 3 - 5 years experience or a M.Sc. with 2 -3 years experience.
    • 2-3 years of pharmaceutical/Biotechnology industrial experience preferred.
    • Demonstrated success in protein/peptides/nucleic acid delivery and the development of novel drug carriers with hands-on experience in lipid nanoparticles formulations & HPLC characterization is a must.
    • Experience with process development/scale-up and a working knowledge of batch record documentation is highly desired.
    • Working knowledge of organic chemistry and its applications to drug delivery is required.
    • Familiarity with lyophilization theory and techniques.
    • Experience handling shipments and procurement of manufacturing supplies is a must.
    • Excellent verbal and written communication skills; clear and concise technical writer.
    • Ability to work in a team environment and support cross functional department activities as needed.
    • Desire to work in a fast-paced environment.

    Required Skills:

    • Hands on experience in operating/Trouble shooting and maintenance of manual and C5 extruder for liposomes preparation.
    • Experience in handling Silverson homogenizer, bench top autoclave and Freeze-dryer.
    • Experience in sterile filtration of liposomes and aseptic filling is required.
    • Ability to characterize liposomes and freeze-dried vaccine formulations using HPLC, particle size analyzer, KF titrators, viscometers etc as per USP compendia methods/in-house methods.
    • Knowledge of computers is essential (Microsoft Excel, Word, PowerPoint and laboratory software packages).
    • Should be able to work independently with minimal supervision.
    • Strong analytical and problem-solving skills.
    • Work well under pressure and ability to multi-task and prioritize.
    • Active team player to support cross functional department activities.

    Preferred skills:

    • Hands on experience in vaccine formulation.
    • Experience shipping materials for external lab testing.
    • Knowledge of regulatory requirements and standards (FDA, EU, ICH, ISO, USP).
    Duties & Responsibilities: 

    Responsibilities

    • Formulation and characterization of sterile freeze dried liposomes/nanoparticles based vaccine products for pre-clinical (both internal and external projects) and toxicology research in accordance with FDA GLP/GMP environment.
    • Support scale-up activities for large scale production of DepoVaxTM formulations (execution, analysis, batch record production).
    • Support product development and cross functional teams for all active projects with liposomes preparation and characterization, freeze-drying, balance/pH meter calibration, autoclaving of manufacturing glassware’s, buffer preparation and vaccine reconstitution as needed.
    • Procure and maintain in-house inventory for manufacturing and clinical trial supplies.
    • Assist in sterile filter validation studies for liposomal formulations.
    • Prepare formulations and carry out shipments for external laboratory testing.
    • Execute or coordinate with third party lab for microbial testing on various dosage forms such as liquids, emulsions and freeze-dried vaccine formulations and troubleshoot if needed.
    • Record all raw data and document day to day activities, computer/instrument generated data in lab notebook as per good documentation practice.
    • Prepare formulation batch records, other technical documents, protocols, SOP’s as required.
    Other Information: 

    A little bit about us

    Immunovaccine Inc

    Strong Science Needs Bright Minds

    At Immunovaccine, we have high standards. And even higher aspirations.

    Our drug candidates are helping us build on this promise. Our technology provides the tools that underscore this mission. And our people are the heart of our operation–the ultimate value-drivers upon which we, as a Company, rest.

    We Work Better Together.

    Curing diseases-especially the ones that continue to evade and outpace even the brightest minds in our industry-is hard work. Despite the intensity and ferocity of our business, the one thing we do not have to worry about is the morale and the spirit of our people. We work hard and we play hard. Our people enjoy our drive, our mission and the road less traveled here in Halifax. As it turns out, that does make all the difference.

    Valuable Work

    We aim high with our mission, so we expect high performance from our people. Whether you are evaluating T cell responses, coordinating clinical operations with our partners, or working with our investor base, we depend on you to help realize the full value of our organization. In turn, we value you, and what you can bring to our Company. We support you in enjoying life fully while working towards your professional goals. Above all, we cultivate the camaraderie that is the hallmark of our corporate culture.

    Happy Employees Produce Strong Results.

    Talk to us about joining the Immunovaccine team.

    Are you interested?

    Work With Us

    Strong Science Needs Bright Minds

    At Immunovaccine, we have high standards. And even higher aspirations.

    Our drug candidates are helping us build on this promise. Our technology provides the tools that underscore this mission. And our people are the heart of our operation–the ultimate value-drivers upon which we, as a Company, rest.

    We Work Better Together.

    Curing diseases-especially the ones that continue to evade and outpace even the brightest minds in our industry-is hard work. Despite the intensity and ferocity of our business, the one thing we do not have to worry about is the morale and the spirit of our people. We work hard and we play hard. Our people enjoy our drive, our mission and the road less traveled here in Halifax. As it turns out, that does make all the difference.

    Valuable Work

    We aim high with our mission, so we expect high performance from our people. Whether you are evaluating T cell responses, coordinating clinical operations with our partners, or working with our investor base, we depend on you to help realize the full value of our organization. In turn, we value you, and what you can bring to our Company. We support you in enjoying life fully while working towards your professional goals. Above all, we cultivate the camaraderie that is the hallmark of our corporate culture.

    Happy Employees Produce Strong Results.

    Talk to us about joining the Immunovaccine team.

    Are you interested?

    Work With Us

    Work environment:

    Our head office is on Summer Street in Halifax, Nova Scotia and we have an office in Quebec City, Quebec. This role will work out of our Halifax, Nova Scotia office. The normal work week is 35 hours, core hours being 9 am – 5 pm. This role will very occasionally see early mornings, extended hours and/ or weekend work depending on the project underway at the time. You will spend most of your time standing in a lab environment. Distance travel is not expected for this position.

    Salary and Benefits:

    This will be a salaried position, depending on skill and experience. Please indicate in your application, your salary expectations and your availability for this position.

    Compensation will be determined based upon skill set and experience of the selected candidate and benchmarking for the position. Immunovaccine offers paid vacation, health/ dental plan, employee assistance program, stock options, and annual bonuses.

    If you feel that you are the best candidate for this position, please apply through the “Apply Now” button.

    Please clearly indicate in your application how you meet the requirements for this role, and why you think you would be the best candidate for the role.

    Applications will be considered upon receipt and until February 9, 2018.

    *We appreciate your application but only candidates selected for interviews will be contacted. We reserve the right to request interview candidates to complete skill/ behavior based assessments as part of the interview process.

    ** The successful candidate will be required to provide a Criminal Record Check before their start date.

    Immunovaccine Inc. is a clinical-stage biopharmaceutical company dedicated to making immunotherapy more effective, more broadly applicable, and more widely available to people facing cancer and infectious diseases. Immunovaccine develops cancer immunotherapies and infectious disease vaccines based on the Company’s DepoVax™ platform, a patented delivery agent that provides controlled and prolonged exposure of antigens and adjuvant to the immune system. Immunovaccine has advanced two T cell activation therapies for cancer through Phase 1 human clinical trials and is currently conducting a Phase 1b study with Incyte Corporation assessing lead cancer therapy, DPX-Survivac, as part of a triple combination therapy in ovarian cancer, as well as a Phase 2 study in recurrent lymphoma. The Company is also advancing an infectious disease pipeline, including innovative vaccines for respiratory syncytial virus (RSV), and currently has clinical projects ongoing to assess the potential of DepoVax™ to address malaria and the Zika virus. (Connect at www.imvaccine.com.)

    Apply Now: https://jobs.careerbeacon.com/details/research-associate-formulation/941763