Job Details

Animal Research Technician

Animal Research Technician
Full Time

Turnstone Biologics Inc.

not disclosed
Date Posted
16/05/2018 - 14:00
Closing Date
16/06/2018 - 14:00
Job Description

Turnstone Biologics is a clinical-stage, immuno-oncology company focused on the development of next-generation oncolytic viral immunotherapies for patients with a broad range of solid tumors. Turnstone’s unique, first-in-class oncolytic viral immunotherapies combine the potent tumor-killing effects of an oncolytic virus with a tumor-targeted T-cell vaccine to harness an individual’s own immune system to attack the tumor, preventing recurrence and delivering a cure. Turnstone’s robust pipeline of early-stage compounds, based on its MG1 oncolytic virus platform, are in development for multiple solid tumors and are being evaluated in combination with other cancer immunotherapies, including checkpoint inhibitors, to drive unprecedented, durable T-cell immune responses and strong anti-tumor activity and prevent recurrence. Turnstone is building a world-class, high-performing company that embraces being a learning organization with a sense of urgency.  Turnstone has a seasoned board of directors and venture capital partners, is enrolling clinical studies, has a rich development portfolio, and highly active R&D efforts led by a world-class scientific management team. Turnstone is co-located in Ottawa, Hamilton, Canada and New York, USA.

The Animal Research Technician is located in Hamilton and will bring hands-on experience with mouse husbandry and procedures such as syngenic murine tumour models, intravenous and intramuscular injections, blood collection and necropsy, including experience with processing blood and tissues for ex vivo analysis. The incumbent will conduct laboratory activities including performing experiments, analyzing data, and will work closely with other lab members.

Education & Qualifications: 
  • BSc in related science; or Medical Laboratory Technology certification; or an equivalent combination of education and experience.
  • 2-5 years’ experience working in research in either an academic or biotech/pharma setting with strong mouse-handling skills
Duties & Responsibilities: 
  • Application of preclinical models to enable the translation of cancer therapies
  • Characterizing in vivo models, ex vivo assays, syngeneic tumour models, mouse models to optimize their application in preclinical and translational studies for targeted therapies, cancer immunotherapies and combination therapies
  • Be highly involved in mouse animal handling requiring subcutaneous, intraperitoneal and intravenous injections, frequent tumor measurements, and regular health monitoring of animals
  • Performs blood collection through multiple routes, gaseous anaesthesia, tissue harvesting, and animal necropsies
  • Be involved in work with culture and/or cell separation methods; virus preparation; drug preparation
  • Provide technical support for assays: viral titration, flow cytometry, and fluorescence microscopy
  • Operate lab equipment such as centrifuges, pH meters, analytical balances, spectrophotometers, light microscopes and other equipment as instructed
  • Performs simple or moderately complex technical procedures
  • Participates in data entry and data analysis, including application of statistical analysis techniques using standard software
  • May perform study-related administrative tasks. Compiles data from related and/or unrelated sources
  • Communicates findings to other lab members and maintains records of experimental data
  • Must have strong interpersonal skills
  • Must have excellent verbal and written communication skills
  • Respond to and complete tasks as instructed by the P.I. and staff associated with designated research projects by carrying out the requested activities
  • Must have a willingness to perform repetitive tasks
  • Action oriented and eager to take on new opportunities and tough challenges with a sense of urgency, high energy, and enthusiasm
  • Ability to work and contribute in a fast-paced, collaborative team environment
Skills & Competencies: 
  • Working knowledge of CCAC guidelines, OMAFRA regulations and animal use protocols (AUPs)
  • Knowledge and familiarity with regulations, standards, and guidelines for care and use of vertebrate animals in teaching, research, and service
  • All work must be performed at the highest quality and with the highest regard for animal welfare.
  • Must have attention to detail and excellent record keeping skills
  • Must possess an excellent work ethic, maintain a professional attitude and maintain high standards to detail, being able to work independently and in a team environment with the ability to interact positively with other team members
  • Must be able to detect, analyze and resolve issues professionally as they arise
Other Information: 

Please forward applications via email only to including a cover letter and resume. In the e-mail subject line, please indicate the position title ANIMAL RESEARCH TECHNICIAN (Hamilton).